insulin detemir + isophane insulin

This drug is a combination of two distinct basal insulins used in the management of diabetes mellitus—insulin detemir and isophane insulin (also known as NPH or neutral protamine Hagedorn insulin). Insulin detemir is a long-acting recombinant human insulin analog that provides prolonged, steady basal insulin coverage with reduced variability and lower risk of hypoglycemia compared to older insulins. Isophane insulin (NPH) is an intermediate-acting human insulin formulation that provides basal glycemic control with an onset of 1–3 hours, peak at 6–8 hours, and duration up to 24 hours. Both agents act by binding to the human insulin receptor, stimulating glucose uptake into muscle and fat tissue while inhibiting hepatic glucose production. The combination would theoretically provide both immediate/intermediate and extended basal glycemic control for patients with type 1 or type 2 diabetes[1][4][7]. There are no widely marketed fixed-dose combinations of these two specific insulins; they are typically used separately or in regimens combining different types for individualized therapy.

Other names

insulin detemir + Insulin Insulatard