insulin glulisine + basal insulin

Combination therapy of **insulin glulisine + basal insulin** refers to a regimen in which a rapid-acting insulin analog (insulin glulisine) is administered alongside a longer-acting basal insulin (such as insulin glargine or insulin detemir). This approach is commonly termed "basal-bolus" therapy, frequently used in both type 1 and type 2 diabetes mellitus. Insulin glulisine is used to control postprandial (after meal) blood glucose surges, while the basal insulin maintains steady glucose levels throughout the day and night. This combination mimics physiological insulin secretion, improving glycemic control, reducing glycation and vascular injury markers, and often improving patient satisfaction[1][2][5].