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insulin-like growth factor binding protein 6 siRNA
- Development stage
- Preclinical
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
01
Overview
insulin-like growth factor binding protein 6 siRNA is a small interfering RNA (siRNA) designed to target and silence the expression of the IGFBP-6 gene. IGFBP-6 is a member of the insulin-like growth factor binding protein family that primarily sequesters insulin-like growth factor 2 (IGF-2), thereby inhibiting its interaction with the IGF-1 receptor and modulating cell growth and survival. In breast cancer research, knockdown of IGFBP-6 using siRNA has been shown to induce cell cycle arrest in the G1 phase, decrease Cyclin B1 levels, and activate interferon signaling pathways. This mechanism suggests that IGFBP-6 plays a role in promoting the G1 to S transition and G2/M progression in certain hormone-responsive and triple-negative breast cancer cell lines, making its silencing a potential therapeutic strategy to inhibit tumor cell proliferation.
- Other names
- IGFBP-6 siRNAIGFBP6 siRNAIGFBP 6 siRNA
02
Targets
IGFBP6 (Insulin-like growth factor-binding protein 6)
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