Drug intelligence / Profile preview

insulin lispro + exenatide

Development stage
Preclinical
Lead developer
Eli Lilly
Modality
Peptides, Small Molecules, Recombinant Proteins and Enzymes
Administration
Subcutaneous
01

Overview

This is a combination of two injectable drugs for diabetes management: - **Insulin lispro** is a rapid-acting synthetic insulin analog that mimics endogenous human insulin, promoting glucose uptake into tissues and inhibiting hepatic glucose production. It is primarily used to control hyperglycemia in type 1 and type 2 diabetes mellitus[1]. - **Exenatide** is a glucagon-like peptide-1 (GLP-1) receptor agonist. It increases glucose-dependent insulin secretion, suppresses inappropriate glucagon secretion, and slows gastric emptying, thereby improving glycemic control in type 2 diabetes mellitus[2][5]. The combination aims to leverage the complementary mechanisms of both agents—insulin replacement and incretin effect—to optimize blood sugar control in people with diabetes.

02

Targets

INSR (Insulin receptor)GLP1R (GLP-1R)

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