Drug intelligence / Profile preview

INT0036

Development stage
Unknown
Lead developer
IntelGenx
Modality
Small Molecules
Administration
Buccal
01

Overview

**INT0036** is an oral thin-film (buccal) formulation of **loxapine**, a dopamine D2 receptor antagonist, developed by **IntelGenx Corp.** using their proprietary **VersaFilm™** technology for the treatment of **schizophrenia**. The technology enables buccal administration, potentially offering faster onset of action, improved bioavailability by bypassing first-pass metabolism, and easier use for patients with swallowing difficulties. A pilot clinical study completed in 2014 demonstrated successful buccal delivery and absorption, confirming the formulation's potential for rapid systemic exposure.

Brand names
Loxapine VersaFilm
Other names
Loxapine oral thin filmLoxapine buccal film
02

Targets

DRD4 (Dopamine D4 Receptor)HTR2A (Serotonin receptor 5-HT2A)HRH1 (Histamine H1 Receptor)DRD1 (Dopamine D1 Receptor)ADRA1A (α1A)DRD2 (Dopamine D2 Receptor)mAChR (Muscarinic acetylcholine receptors)

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