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INTERCEPT Blood System-treated platelets
- Development stage
- Unknown
- Lead developer
- Cerus Corporation
- Modality
- Cell Therapies
- Administration
- Intravenous
01
Overview
Pathogen-reduced platelet concentrates are biological blood products treated with the INTERCEPT Blood System to enhance transfusion safety. The process involves the addition of amotosalen (a photoactive compound) to platelet units, followed by illumination with ultraviolet A (UV-A) light. This treatment induces permanent covalent cross-linking of nucleic acids, effectively inactivating a broad spectrum of viruses, bacteria, and parasites, as well as residual donor white blood cells, thereby preventing transfusion-transmitted infections and transfusion-associated graft-versus-host disease. In the EFFIPAP trial, sponsored by the Etablissement Français du Sang, these platelets were evaluated for hemostatic efficacy in patients with thrombocytopenia resulting from bone marrow aplasia or malignant hematologic diseases.
- Brand names
- INTERCEPT Blood System
- Other names
- Pathogen-reduced platelet concentratesAmotosalen-UVA treated platelets
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