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interferon α-2b + arsenic trioxide + venetoclax
- Development stage
- Unknown
- Lead developer
- Zhejiang Provincial People's Hospital
- Modality
- Cytokines & Interferons → Recombinant Proteins and Enzymes, Small Molecules
- Administration
- Intravenous, Subcutaneous, Oral
01
Overview
This combination therapy, consisting of interferon α-2b, arsenic trioxide (ATO), and venetoclax, is being investigated by Zhejiang Provincial People's Hospital for the treatment of arsenic-resistant relapsed acute promyelocytic leukemia (APL). Interferon α-2b is a recombinant Type I interferon that exerts antiproliferative and immunomodulatory effects by binding to specific cell-surface receptors. Arsenic trioxide is a mainstay of APL treatment that induces the degradation of the PML-RARA fusion protein, leading to cell differentiation and apoptosis. Venetoclax is a potent, selective oral B-cell lymphoma 2 (BCL-2) inhibitor that restores the apoptotic process in cancer cells. This triplet regimen is designed to overcome therapeutic resistance in patients who have failed standard arsenic-based induction and consolidation therapies.
- Other names
- Interferon-α combined with ATO and Venetoclaxinterferon α-2b + arsenic trioxide + venetoclax
02
Targets
BCL-2 (BCL-2 family)NFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)IFNAR2 (Interferon alpha/beta receptor subunit 2)IFNAR (Immune system modulation via type I interferon receptor)PML-RARA (PML-retinoic acid receptor alpha fusion protein)
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