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Drug intelligence / Profile preview
interferon alfa-2a + adefovir
- Development stage
- Preclinical
- Lead developer
- Roche
- Modality
- Cytokines & Interferons → Recombinant Proteins and Enzymes, Small Molecules
- Administration
- Oral, Subcutaneous
01
Overview
This drug is a combination of interferon alfa-2a and adefovir. Interferon alfa-2a is a recombinant cytokine that binds to the interferon alpha/beta receptor, activating intracellular signaling pathways that induce antiviral, antiproliferative, and immunomodulatory effects. Adefovir (commonly abbreviated as ADV) is an oral nucleotide analog reverse transcriptase inhibitor with potent activity against hepatitis B virus (HBV); it inhibits viral DNA polymerase by competing with natural substrates and causing chain termination during viral replication. The combination has been explored for the treatment of chronic hepatitis B infection to enhance antiviral efficacy by combining immune modulation (interferon) with direct inhibition of HBV replication (adefovir).
- Other names
- interferon alfa-2a + ADVinterferon alpha-2a + adefovir
02
Targets
HBV Pol (Hepatitis B virus polymerase)POLA1 (DNA polymerase alpha)POLG (Mitochondrial DNA polymerase gamma)IFNAR (Immune system modulation via type I interferon receptor)IFNAR1 (Interferon alpha/beta receptor 1)
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