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interferon alfacon-1 + interferon gamma-1b
- Development stage
- Preclinical
- Lead developer
- Amgen
- Modality
- Cytokines & Interferons → Recombinant Proteins and Enzymes
- Administration
- Subcutaneous
01
Overview
A combination of **interferon alfacon-1** (a recombinant type-I consensus interferon alpha) and **interferon gamma-1b** (a recombinant type-II interferon gamma) designed to provide synergistic antiviral and immunomodulatory effects. Interferon alfacon-1 acts primarily by inducing antiviral proteins and modulating immune responses, while interferon gamma-1b activates macrophages and enhances antigen presentation, leading to increased expression of immunomodulatory and antiviral genes. The combination is experimental and has been studied for enhanced antiviral activity in models of viral infections, including hepatitis C, and is backed by preclinical and limited clinical data suggesting potential utility in patients who have failed standard therapies.
- Other names
- consensus interferon + interferon gamma-1bIFN alfacon-1 + IFN gamma-1b
02
Targets
IFNGR1 (Interferon gamma receptor 1)IFNAR (Immune system modulation via type I interferon receptor)
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