interleukin-21 receptor Fc fusion protein

Interleukin-21 receptor Fc fusion protein (IL-21R-Fc) is a recombinant fusion protein consisting of the extracellular domain of the interleukin-21 receptor (IL-21R) fused to the Fc region of an immunoglobulin (typically IgG). It acts as a soluble decoy receptor (ligand trap) that binds to and neutralizes interleukin-21 (IL-21), thereby blocking IL-21/IL-21R signaling. IL-21 is a pleiotropic cytokine produced primarily by activated CD4+ T cells (including Th17 and follicular helper T cells) that plays a critical role in both innate and adaptive immune responses, promoting B-cell differentiation into antibody-secreting plasma cells, CD8+ T-cell and NK-cell activation, and Th17 cell development. Preclinical studies have demonstrated that IL-21R-Fc can ameliorate disease severity in animal models of various autoimmune and inflammatory conditions, including type 1 diabetes, systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, and allergic skin inflammation. While IL-21R-Fc has been widely utilized as a research reagent to investigate the role of IL-21 signaling in vivo and in vitro, clinical development of IL-21 pathway inhibitors has primarily focused on monoclonal antibodies targeting IL-21 or IL-21R.

Other names

IL-21 receptor Fc fusion proteinIL21 receptor Fc fusion proteinIL 21 receptor Fc fusion proteinIL-21 receptor-Fc fusion proteinIL21 receptor-Fc fusion proteinIL 21 receptor-Fc fusion proteinIL-21R FcIL21R FcIL 21R FcIL-21R-FcIL21R-FcIL 21R-FcIL-21R.FcIL21R.FcIL 21R.FcIL-21R:Fcinterleukin-21 receptor-Fc fusion proteininterleukin21 receptor-Fc fusion proteininterleukin 21 receptor-Fc fusion proteinrecombinant human interleukin-21 receptor/Fc chimerarecombinant mouse interleukin-21 receptor/Fc chimerasoluble IL-21 receptor-Fc fusion protein