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Intestinal bacteria freeze-dried powder capsules

Development stage: Unknown
Lead developer: Yun-fei Xia
Modality: Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration: Oral

Overview

Intestinal bacteria freeze-dried powder capsules are an oral formulation used for fecal microbiota transplantation (FMT). This microbial therapy is designed to modulate the gut microbiome to enhance the therapeutic efficacy of immune checkpoint inhibitors and chemotherapy in patients with metastatic nasopharyngeal carcinoma. By restoring a healthy microbial balance, the treatment aims to overcome primary resistance to PD-1 antibodies, such as toripalimab, and mitigate the toxic side effects associated with long-term chemotherapy regimens like PFLL (cisplatin, fluorouracil, and leucovorin). It is currently being investigated in Phase III clinical trials led by Yun-fei Xia to determine if regulating gut microbiota can improve anti-tumor reactivity and patient outcomes.

Other names: Fecal microbiota transplantationFMTHealthy intestinal bacteria freeze-dried powder capsules

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