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Intestinal Microbiota Transplantation

Development stage: Unknown
Lead developer: University of Minnesota
Modality: Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration: Nasogastric

Overview

Intestinal Microbiota Transplantation (IMT) is a microbial therapy being developed and investigated by the University of Minnesota, specifically for patients undergoing colon resection due to diverticulitis or sigmoid colon cancer. The intervention involves the administration of a prepared solution containing a diverse community of live microorganisms derived from healthy donor feces. In this specific clinical protocol, the IMT solution is delivered via a nasogastric feeding tube on postoperative day 2 or 3, following the administration of intravenous antibiotics. The primary goal is to restore the gut microbiome's diversity and function, which is typically disrupted by surgery and antibiotic treatment, thereby evaluating the safety and feasibility of this approach in a surgical recovery context.

Other names: Fecal Microbiota TransplantationFMTIMT solution

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