intra-bone cord blood hematopoietic stem cell transplantation

This therapeutic procedure involves the direct intra-bone injection of allogeneic hematopoietic stem cells derived from umbilical cord blood (UCB). Developed by the Università degli Studi di Brescia, specifically under the leadership of Dr. Domenico Russo, this cell-based biologic therapy is designed for adult patients with hematologic malignancies—such as acute leukemias and myelodysplastic syndromes—who lack a suitable HLA-matched donor. By injecting the cells directly into the bone marrow space rather than using conventional intravenous infusion, the technique aims to enhance engraftment kinetics and allow for successful transplantation using significantly lower cell doses. This approach addresses a major limitation of cord blood transplantation in adults, where single UCB units often contain insufficient cell numbers for the patient's body weight.

Other names

IB-CBCTIntra-bone cord blood transplantationIntrabone HSC infusion of CB