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Drug intelligence / Profile preview
intranasal COVID-19 DNA vaccine
- Development stage
- Preclinical
- Lead developer
- AnGes
- Modality
- Prophylactic Vaccines → Vaccines & Immunotherapeutics, DNA Vaccines → Plasmid DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Nanoparticles → Drug Delivery Systems
- Administration
- Intranasal
01
Overview
This intranasal DNA vaccine for COVID-19 is being developed by AnGes, Inc. in collaboration with Osaka University and Stanford University School of Medicine. The vaccine utilizes a plasmid DNA-based formulation that encodes the SARS-CoV-2 spike protein. It is delivered through the nasal mucous membranes using Gold-Nanostar Octopod technology, which is designed to enhance delivery and potentially induce mucosal immunity. This program represents a strategic shift for AnGes, which discontinued its original intramuscular DNA vaccine (targeting the Wuhan strain) in September 2022 to focus on this improved intranasal formulation specifically designed to address COVID-19 variants.
- Other names
- intranasal COVID-19 vaccine (Stanford University Gold-Nanostar Octopod)AnGes intranasal COVID-19 DNA vaccine
02
Targets
SARS-CoV-2 spike
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