intrauterine autologous platelet-rich plasma

Intrauterine autologous platelet-rich plasma (PRP) is a regenerative therapy in which a concentrated preparation of platelets derived from the patient's own whole blood is infused directly into the uterine cavity. The process involves collecting peripheral blood, centrifuging it to achieve a 4–5-fold increase in platelet concentration over baseline, and then infusing this concentrate into the uterus[2][5]. Platelets contain alpha granules rich in growth factors and cytokines that are released upon activation. These bioactive molecules promote tissue regeneration, modulate inflammation, and enhance endometrial receptivity by stimulating cellular proliferation and angiogenesis[1][3][7]. In reproductive medicine, intrauterine PRP has been investigated primarily for improving endometrial thickness and pregnancy outcomes in women with repeated implantation failure (RIF) or thin endometrium undergoing assisted reproductive technology (ART)[1][4][5]. The mechanism of action centers on delivering high concentrations of growth factors such as transforming growth factor-beta (TGF-β), vascular endothelial growth factor (VEGF), interleukin-8 (IL-8), and others to the endometrium to support regeneration and improve embryo implantation rates[1][5].

Other names

intrauterine PRPintrauterine autologous PRPintrauterine infusion of autologous platelet-rich plasma