intravenous drug-Minia University-post-dural puncture headache-postoperative nausea and vomiting

This entry refers to the intravenous pharmacological interventions—specifically **ondansetron** and **dexamethasone**—evaluated in a clinical trial conducted by **Minia University** (NCT03440307). The study was designed as a randomized, double-blind trial to compare the efficacy of these two agents in preventing **post-dural puncture headache (PDPH)** and **postoperative nausea and vomiting (PONV)** in parturients undergoing elective Caesarean section under spinal anesthesia. Ondansetron is a selective 5-HT3 receptor antagonist typically used as an antiemetic, while dexamethasone is a potent synthetic glucocorticoid with anti-inflammatory and antiemetic properties. The trial aimed to determine if either drug could effectively reduce the incidence of PDPH, a common complication of spinal anesthesia, alongside their established roles in managing PONV.

Other names

Intravenous drug