Drug intelligence / Profile preview

Intravenous Human Immunoglobulin (pH4) (Wuhan Zhong Yuan Rui De)

Development stage
Phase 3
Lead developer
Wuhan Zhong Yuan Rui De Biological Products
Modality
Recombinant Proteins and Enzymes
Administration
Intravenous
01

Overview

Human Immunoglobulin (pH4) for Intravenous Injection is a plasma-derived biologic developed by Wuhan Zhong Yuan Rui De Biological Products, a subsidiary of Beijing Tiantan Biological Products. It consists of pooled human immunoglobulin G (IgG) antibodies purified from healthy donor plasma and formulated at pH 4.0 to maintain stability and prevent protein aggregation. The product is indicated for replacement therapy in patients with primary or secondary immunodeficiency syndromes and for immunomodulation in various immune-mediated diseases, such as idiopathic thrombocytopenic purpura (ITP) and Kawasaki disease. It provides passive immunity by supplying a broad spectrum of antibodies and modulates the recipient's immune response through mechanisms including Fc receptor interaction and complement system regulation.

Brand names
蓉生静丙Rongsheng Jingbing
Other names
静注人免疫球蛋白(pH4)IVIG pH4Human Immunoglobulin (pH4) for Intravenous Injection
02

Targets

FCGR1A (High affinity immunoglobulin gamma fc receptor I)FCGR2A (Low affinity immunoglobulin gamma Fc receptor II-a)FCGR2B (Fc gamma receptor IIB)FCGR3A (Low affinity immunoglobulin gamma Fc region receptor III-A)

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