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Intravenous hypotonic solution, specifically 5% glucose (D5W), is a crystalloid fluid used for the correction of hypernatremia. In the context of a clinical trial led by the Hospital Civil de Guadalajara, this solution is administered intravenously to provide free water, which dilutes elevated serum sodium levels (defined as >145 mEq/L). For patients with hyperglycemia, the protocol utilizes a modified solution consisting of a 1:1 mixture of 5% glucose and injectable water, resulting in a 2.5% glucose solution. The treatment aims to safely restore electrolyte balance in hospitalized and intensive care patients by providing free water that equilibrates across fluid compartments.
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