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Intravenous Ibuprofen (IVIb) is a pharmaceutical drug used for the management of pain and fever, particularly in postoperative settings and for conditions like traumatic rib fractures. As a non-steroidal anti-inflammatory drug (NSAID), its mechanism of action involves the inhibition of cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2, which leads to a reduction in prostaglandin synthesis. This inhibition results in analgesic, antipyretic, and anti-inflammatory effects. Studies have shown IVIb to be effective in reducing postoperative pain, fever, and opioid consumption, with a favorable safety profile.
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