Drug intelligence / Profile preview

InvVax Universal Flu Vaccine

Development stage
Preclinical
Lead developer
InvVax
Modality
Vaccines & Immunotherapeutics
Administration
Subcutaneous, Intranasal
01

Overview

InvVax Universal Flu Vaccine is a preclinical-stage universal influenza vaccine candidate developed by InvVax. The vaccine utilizes an adenoviral vector to deliver 15 highly invariant influenza T-cell epitopes, including HLA-B27-restricted peptides, which were identified through a systematic functional genomic screen of the influenza genome. By targeting these invariant regions—which are critical to viral survival and cannot mutate without compromising viral fitness—the vaccine aims to induce broad, cross-protective cellular immunity against multiple influenza strains, including H1N1, H3N2, and highly pathogenic avian influenza (H5N1).

Other names
Human 15-epitope adenoviral-vectored universal influenza vaccineHuman15-epitope adenoviral-vectored universal influenza vaccineHuman-15-epitope adenoviral-vectored universal influenza vaccineInvVax universal influenza vaccine
02

Targets

MHC I (MHC class I})MHC II (Major histocompatibility complex class II receptor)γδ TCR (T-cell receptor)

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