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IO-VAC

Development stage: Preclinical
Lead developer: IOZK
Modality: Vaccines & Immunotherapeutics, Oncolytic Viruses → Oncolytic Therapeutics, Dendritic Cell Vaccines → Immune Effector Cells → Other Cell Types → Cell Therapies
Administration: Intradermal

Overview

**IO-VAC** is an individualized autologous dendritic-cell cancer vaccine developed and manufactured by IOZK. It is prepared from patient-derived monocytes differentiated into dendritic cells and loaded with antigens from the patient's own tumor-cell lysate together with immunostimulatory danger signals derived from Newcastle disease virus. The administered dendritic cells present tumor-associated antigens to the immune system, aiming to activate tumor-reactive T cells and establish antitumor immune memory. IO-VAC is used within IOZK's personalized multimodal immunotherapy approach for cancer and is not described by IOZK as a standard approved oncology treatment. ([iozk.de](https://www.iozk.de/en/the-iozk-immunotherapy/io-vac-vaccine/))

Brand names: IO-VAC
Other names: dendritic cell vaccine (IO-VAC)personalized dendritic cell-based tumor vaccine

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