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IO170
- Development stage
- Phase 1
- Lead developer
- IO Biotech
- Modality
- Vaccines & Immunotherapeutics, Peptides
01
Overview
IO170 is a **TGF-β peptide vaccine** developed by IO Biotech. It targets Transforming Growth Factor Beta (TGF-β), a key immune-suppressive factor in solid tumors. The vaccine has shown significant tumor growth reduction in pancreatic adenocarcinoma and prostate cancer models by inducing robust immune responses and reshaping the tumor microenvironment without systemic toxicity[1][2][4].
- Other names
- TGF-beta-15 peptideTGF-beta15 peptideTGF-beta 15 peptideTGF-beta-15 peptide vaccineTGF-beta15 peptide vaccineTGF-beta 15 peptide vaccine
02
Targets
Transforming growth factor beta-expressing cells via transforming growth factor beta-derived peptide-MHC complexesTGFB (GARP–latent transforming growth factor beta 1 complex)
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