iobenguane (123I) (GE HealthCare)

Iobenguane (123I), also known as iodine-123-metaiodobenzylguanidine (123I-MIBG), is a diagnostic radiopharmaceutical agent. It is a radioiodinated synthetic analog of the neurotransmitter norepinephrine (noradrenaline) and is structurally related to guanethidine. Iobenguane (123I) is actively transported into adrenergic nerve endings and neuroendocrine cells via the norepinephrine transporter (NET) and stored in neurosecretory granules. It is primarily used in nuclear medicine for diagnostic imaging (scintigraphy) to detect, localize, and stage neuroendocrine tumors, such as pheochromocytomas, paragangliomas, and neuroblastomas. Additionally, it is approved for the scintigraphic assessment of myocardial sympathetic innervation to evaluate cardiac nerve activity and estimate mortality risk in patients with congestive heart failure.

Brand names

AdreView

Other names

123I-MIBGiobenguane I 123iobenguane I-123iobenguane sulfate I 123iobenguane sulfate I-123iodine I 123-metaiodobenzylguanidineiodine-123-metaiodobenzylguanidineiodine123-metaiodobenzylguanidineiodine 123-metaiodobenzylguanidinemIBG I 123mIBG I-123meta-iodobenzylguanidine I 123meta-iodobenzylguanidine I-123