Drug intelligence / Profile preview

iodine-123

Development stage
Phase 1
Modality
Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration
Oral, Intravenous
01

Overview

Iodine-123 is a radioactive isotope of iodine with a half-life of approximately 13.2 hours. It decays by electron capture to tellurium-123, emitting gamma radiation with a characteristic energy of 159 keV, which is ideal for medical imaging. It is primarily used as a radiopharmaceutical diagnostic agent for the evaluation of thyroid function and morphology. The thyroid gland actively absorbs iodine from the bloodstream to synthesize thyroid hormones, making radioactive iodine an effective tool for assessing thyroid function. Iodine-123 is also used as a label in other imaging radiopharmaceuticals, such as metaiodobenzylguanidine (MIBG) and ioflupane (DaTscan), which are used for diagnosing neurological disorders like Parkinson's disease.

Brand names
DaTscan
Other names
I-123I123I 123123IIodide I-123Iodide ion i-123Iodine 123Iodine123Iodine-123Iodine-123 sodium iodideIodine123 sodium iodideIodine 123 sodium iodide
02

Targets

NIS (Human sodium iodide symporter)

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