iodine 123-labeled cis-11β-methoxy-17α-iodovinyl estradiol

A radiopharmaceutical agent used for noninvasive imaging of estrogen receptors in breast cancer. Iodine 123-labeled cis-11β-methoxy-17α-iodovinyl estradiol (Z-MIVE) is a synthetic estrogen analog labeled with the radioisotope iodine‑123. It binds with high affinity to estrogen receptor, allowing for scintigraphic detection and quantification of estrogen receptor expression in primary and metastatic breast tumors using planar scintigraphy or single photon emission computed tomography (SPECT). This agent enables assessment of estrogen receptor status to guide therapy decisions and predict response to antiestrogen treatments such as tamoxifen. The compound demonstrates high sensitivity and specificity for detecting estrogen receptor-positive lesions, with uptake blocked by antiestrogens confirming receptor-mediated binding[1][2][3][6]. Dosimetry studies indicate acceptable radiation exposure for clinical imaging[5].

Other names

iodine 123-labeled cis-11beta-methoxy-17alpha-iodovinyl estradioliodine123-labeled cis-11beta-methoxy-17alpha-iodovinyl estradioliodine-123-labeled cis-11beta-methoxy-17alpha-iodovinyl estradiol123I-labeled cis-11β-methoxy-17α-iodovinyl estradiol