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iodine-125 methylene blue
- Development stage
- Unknown
- Lead developer
- Louisiana State University Health Sciences Center
- Modality
- Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Peritumoral, Intradermal, Subcutaneous, Intramammary
01
Overview
**Iodine-125 methylene blue** is an investigational dual-modality radiolabeled dye used for intraoperative sentinel lymph node mapping in women with breast cancer. Following subcutaneous periareolar injection, methylene blue travels through lymphatic channels and visually stains draining sentinel lymph nodes, while its iodine-125 label provides a gamma-detectable signal for surgical localization. An extended Phase II study reported successful sentinel-node identification in 94% of enrolled patients and supported its use as an intraoperatively prepared alternative to technetium-99m sulfur colloid plus blue dye. ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23521938/))
- Other names
- iodine-125-labeled methylene blueiodine125-labeled methylene blueiodine 125-labeled methylene blue125I-MB
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