Drug intelligence / Profile preview

iodine-131

Development stage: Approved
Lead developer: Carlo Chiesa
Modality: Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration: Oral

Overview

Iodine-131 is a radioactive isotope of iodine used as a radiopharmaceutical for the treatment of differentiated thyroid cancer and hyperthyroidism. This specific entry refers to a personalized therapeutic approach studied by Carlo Chiesa, which utilizes pre-treatment Iodine-124 PET dosimetry to optimize the administered activity of Iodine-131 in patients with metastatic differentiated thyroid cancer. The drug is selectively sequestered by thyroid cells via the sodium-iodide symporter (NIS). Once internalized, it emits beta radiation that causes localized DNA damage and cell death in thyroid tissue and metastatic lesions. The personalized dosimetry protocol aims to improve therapeutic efficacy and overcome radioresistance by tailoring the radioactive dose to individual lesion uptake and blood clearance rates.

Brand names: HiconIodotope
Other names: RadioiodineSodium iodide I-131Radioactive iodine

Targets

NIS (Human sodium iodide symporter)DNA

Beyond the preview

Go deeper on iodine-131.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

Trial phase
Status
Readouts

Indications & development

Explore development by indication, patient population, and geography.

Indications
Development status
Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

Partners
Deal terms
Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

Patents
Expiration dates
Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

Competing assets
Targets
Development stage

Research & analysis

Connect source evidence and development news to your research questions.

Publications
News
Analysis

Bring the full picture into focus.

See how Gosset can support your research on iodine-131.

Explore the full profile