iodine i 131 + F16SIP

**Iodine i 131 + F16SIP** is a combination therapy under investigation for cancer treatment, especially targeting tumors that express fibronectin, including certain thyroid, lung, and other solid tumors. Iodine i 131 is a radioactive isotope commonly used as a radiopharmaceutical for therapy and imaging, particularly in thyroid conditions, where it is selectively taken up by thyroid tissue and emits beta and gamma radiation to destroy targeted cells. F16SIP is an antibody fragment (small immunoprotein, SIP) targeting the extra-domain A of fibronectin, a marker highly expressed in the extracellular matrix of tumor vasculature. When radiolabeled with iodine-131, F16SIP serves as a tumor-targeted radiotherapeutic, delivering cytotoxic radiation directly to tumor tissue and minimizing off-target adverse effects.

Other names

iodine-131 + F16SIP