iodo-willardiine

Iodo-willardiine is a synthetic analog of the amino acid willardiine and acts as a highly potent and selective agonist for kainate receptors containing GluK1 (also known as GluR5) subunits. It exhibits high selectivity for these kainate receptor subtypes with an EC50 value of approximately 0.21 µM and shows minimal activity at AMPA receptors or other kainate receptor subunits such as GluK2, GluK6, or GluK7. Iodo-willardiine has been widely used in research to characterize the function of specific kainate receptor subtypes in neuronal signaling, apoptosis, necrosis, and neuropathic pain models. It is considered an experimental tool compound rather than a therapeutic drug[3][4][5].

Other names

(S)-(-)-5-IodowillardiineS-5-IodowillardiineS5-IodowillardiineS 5-Iodowillardiine(s)-5-Iodowillardiine5-Iodowillardiine5-(S)-Iodowillardiine(2S)-2-amino-3-(5-iodo-2,4-dioxopyrimidin-1-yl)propanoic acid2-amino-3-(5-Iodo–2,4-dioxo–3,4-dihydro–2H-pyrimidin–1–yl)propionic acid