Drug intelligence / Profile preview

Iodohippurate sodium I-131

Development stage
Unknown
Modality
Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Beta-minus Emitters → Radiopharmaceuticals, Gamma Emitters → Radiopharmaceuticals, Small Molecules
Administration
Intravenous
01

Overview

Iodohippurate sodium I-131 is a radiopharmaceutical small molecule consisting of the organic compound iodohippuric acid labeled with radioactive iodine isotope (Iodine-131). It is primarily used as a diagnostic agent to evaluate renal plasma flow and kidney function. The mechanism of action involves its rapid filtration and secretion by the kidneys, allowing for assessment of renal perfusion and excretory capacity using gamma camera imaging. The radioisotope emits both beta and gamma radiation; the gamma emissions enable imaging while the beta emissions contribute to tissue effects. This agent is not typically used for therapeutic purposes but rather for functional diagnostics in nuclear medicine[1].

Brand names
Hipputope
Other names
sodium 2-((131)I)iodohippuratesodium iodohippurate I-131hippuran I-131
02

Targets

OAT1 (Organic anion transporter 1)SLC22A8 (Organic anion transporter 3)

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