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Ioflupane F-18
- Development stage
- Phase 3
- Modality
- Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
Ioflupane F-18 is a cocaine analog radiopharmaceutical with high affinity for the dopamine transporter. It is used as an imaging agent in positron emission tomography (PET) studies to visualize and quantify dopamine transporter density in the brain. The primary clinical application is in the diagnosis of Parkinson's disease and related neurodegenerative disorders by assessing dopaminergic neuron integrity. Ioflupane F-18 binds selectively to presynaptic dopamine transporters, allowing visualization of striatal uptake patterns that are characteristic of Parkinsonian syndromes[1]. The compound was approved in Korea for this indication.
- Brand names
- PDvue
- Other names
- Ioflupane F-1818F-beta-CIT-FP
02
Targets
DAT (Dopamine plasma membrane transport protein)
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