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ionomycin
- Development stage
- Unknown
- Lead developer
- Streptomyces conglobatus
- Modality
- Small Molecules
- Administration
- In Vitro (laboratory Use Only)
01
Overview
Ionomycin is a polyether antibiotic and a selective calcium ionophore produced by the bacterium Streptomyces conglobatus. It binds divalent cations with high selectivity for Ca2+ over Mg2+, facilitating the transport of calcium ions across biological membranes. Ionomycin is widely used as a research tool to increase intracellular calcium levels, enabling studies of Ca2+-dependent cellular processes such as signal transduction, apoptosis, and cytokine production. It can induce cell activation and promote apoptosis by activating protein kinase C (PKC) pathways and other downstream signaling cascades[1][5][6]. Ionomycin is not approved for clinical use in humans but is extensively utilized in laboratory research.
- Other names
- 离子霉素ionomycin calcium salt
02
Targets
Biological membrane lipid bilayer
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