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IONP-TNA@Man
- Development stage
- Preclinical
- Lead developer
- National Cheng Kung University
- Modality
- Nanoparticles → Drug Delivery Systems
01
Overview
IONP-TNA@Man (also known as IONP-TNA@MA) is a d-mannose-modified iron oxide-tannic acid nanoparticle designed for the photothermal treatment of bacterial infections, particularly those caused by extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli (E. coli). The nanoparticle is synthesized via a tannic acid (TNA)-assisted hydrothermal reaction that converts iron oxide nanopowder (IONP) into black colloidal Fe3O4 nanoparticles, which are subsequently modified with d-mannose. The d-mannose moiety targets the FimH adhesin on the bacterial membrane, allowing the nanoparticles to adhere specifically to E. coli. Upon exposure to near-infrared (NIR) light (e.g., 808 nm), the nanoparticles exhibit high photon-to-thermal conversion, generating localized heat that destroys the bacteria with minimal cytotoxicity to human urothelial cells.
- Other names
- Fe3O4@TNA@MAFe3O4@TNA@Mand-mannose-modified iron oxide-tannic acid nanoparticlesiron oxide-tannic acid-mannose nanoparticles
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