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Iopanoic acid
- Development stage
- Discontinued
- Lead developer
- GE Healthcare
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Iopanoic acid is an iodine-containing small molecule radiocontrast agent formerly used in cholecystography. It acts as a potent inhibitor of thyroid hormone release from the thyroid gland and inhibits the peripheral conversion of thyroxine (T4) to triiodothyronine (T3) by blocking thyroxine 5'-deiodinase enzymes. This mechanism makes it effective for rapid control of hyperthyroidism, particularly in severe cases or when standard antithyroid therapies are ineffective or contraindicated. Iopanoic acid has also been used as adjunctive therapy before thyroidectomy and in neonatal thyrotoxicosis. Its use for treating thyrotoxicosis has been discontinued in several countries, including the United States[1][2][4][5].
- Other names
- Acidum iopanoicumiodopanoic acid
02
Targets
DIO1 (Type I iodothyronine deiodinase)DIO2 (Iodothyronine deiodinase type 2)DIO3 (Thyroxine 5'-deiodinase)
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