Drug intelligence / Profile preview

ipatasertib + cobimetinib + trastuzumab emtansine + atezolizumab + giredestrant + abemaciclib + inavolisib + palbociclib + olaparib + bevacizumab

Development stage
Preclinical
Lead developer
Roche
Modality
Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration
Oral, Intravenous
01

Overview

This is a combination regimen comprising ten anti-cancer drugs: **ipatasertib** (selective AKT inhibitor), **cobimetinib** (MEK1/2 inhibitor), **trastuzumab emtansine** (HER2-targeted antibody-drug conjugate), **atezolizumab** (PD-L1 immune checkpoint inhibitor), **giredestrant** (selective estrogen receptor degrader), **abemaciclib** and **palbociclib** (CDK4/6 inhibitors), **inavolisib** (PI3Kα inhibitor), **olaparib** (PARP inhibitor), and **bevacizumab** (VEGF-A inhibitor). These agents act across multiple oncogenic pathways: PI3K/AKT/mTOR, MAPK/ERK, cell cycle regulation, DNA repair, HER2, immune checkpoint, angiogenesis, and hormone-dependent signaling. The combination does not correspond to a marketed product but consists of individual drugs, each with established roles in targeted therapy, hormonal therapy, immunotherapy, and antiangiogenic therapy, primarily for advanced or metastatic solid tumors.

02

Targets

AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)AKT2 (Rac-beta serine/threonine-protein kinase)AKT3 (RAC-gamma serine/threonine-protein kinase)ERBB2 (Erb-b2 receptor tyrosine kinase 2)MEK1 (Dual specificity mitogen-activated protein kinase kinase 1)MEK2 (Dual specificity mitogen-activated protein kinase kinase 2)CD274 (Programmed cell death protein 1 ligand 1)CDK4 (Cyclin-dependent kinase 4)CDK6 (Cyclin-dependent kinase 6)ESR1 (ERα)PIK3CA (Phosphoinositide 3-kinase alpha)PARP1 (Poly (adp-ribose) polymerase 1)VEGFA (Vascular endothelial growth factor A)

Beyond the preview

Go deeper on ipatasertib + cobimetinib + trastuzumab emtansine + atezolizumab + giredestrant + abemaciclib + inavolisib + palbociclib + olaparib + bevacizumab.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

  • Trial phase
  • Status
  • Readouts

Indications & development

Explore development by indication, patient population, and geography.

  • Indications
  • Development status
  • Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

  • Partners
  • Deal terms
  • Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

  • Patents
  • Expiration dates
  • Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

  • Competing assets
  • Targets
  • Development stage

Research & analysis

Connect source evidence and development news to your research questions.

  • Publications
  • News
  • Analysis

Bring the full picture into focus.

See how Gosset can support your research on ipatasertib + cobimetinib + trastuzumab emtansine + atezolizumab + giredestrant + abemaciclib + inavolisib + palbociclib + olaparib + bevacizumab.

Gosset Free

Get started with Gosset.

Enter your corporate email.

Work email preferred.

Book a call