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ipatasertib + cobimetinib + trastuzumab emtansine + atezolizumab + giredestrant + abemaciclib + inavolisib + palbociclib + olaparib + bevacizumab

Development stage
Preclinical
Lead developer
Roche
Modality
Small Molecules, Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
Administration
Oral, Intravenous
01

Overview

This is a combination regimen comprising ten anti-cancer drugs: **ipatasertib** (selective AKT inhibitor), **cobimetinib** (MEK1/2 inhibitor), **trastuzumab emtansine** (HER2-targeted antibody-drug conjugate), **atezolizumab** (PD-L1 immune checkpoint inhibitor), **giredestrant** (selective estrogen receptor degrader), **abemaciclib** and **palbociclib** (CDK4/6 inhibitors), **inavolisib** (PI3Kα inhibitor), **olaparib** (PARP inhibitor), and **bevacizumab** (VEGF-A inhibitor). These agents act across multiple oncogenic pathways: PI3K/AKT/mTOR, MAPK/ERK, cell cycle regulation, DNA repair, HER2, immune checkpoint, angiogenesis, and hormone-dependent signaling. The combination does not correspond to a marketed product but consists of individual drugs, each with established roles in targeted therapy, hormonal therapy, immunotherapy, and antiangiogenic therapy, primarily for advanced or metastatic solid tumors.

02

Targets

MEK2 (Dual specificity mitogen-activated protein kinase kinase 2)AKT2 (Rac-beta serine/threonine-protein kinase)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)ERBB2 (Erb-b2 receptor tyrosine kinase 2)CD274 (Programmed cell death protein 1 ligand 1)MEK1 (Dual specificity mitogen-activated protein kinase kinase 1)

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