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iPB postbiotic
- Development stage
- Preclinical
- Lead developer
- NutriTechLab
- Modality
- Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
iPB postbiotic is an innovative postbiotic product developed through the sequential fermentation of *Lacticaseibacillus rhamnosus* GG and *Lacticaseibacillus paracasei* NPB-01 (DSM 34367). It is designed to enhance epithelial gut barrier integrity, modulate innate immunity, and exert antitumor activities, particularly against breast cancer. In preclinical models, iPB has been shown to reduce cell viability and migration across various breast cancer subtypes (including MCF7, MDA-MB-231, and SKBR3) while increasing apoptosis and HLA class I surface expression, which potentially enhances immunogenicity. Additionally, it upregulates tight junction proteins (such as occludin and zonula occludens 1) and mucin-2 (MUC2) expression, and stimulates the production of human beta-defensin 2 (HBD-2) in human enterocytes.
- Other names
- innovative postbiotic productsequential postbiotic
02
Targets
HCAR2 (Hydroxycarboxylic acid receptor 2)FFAR3 (Free fatty acid receptor 3)FFAR2TLR2 (Toll-like Receptor 2)TLR4 (Toll-like receptor 4)
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