Drug intelligence / Profile preview

IPM001

Development stage
Phase 1
Lead developer
Beijing Zhenzhi Medical Technology
Modality
Cell Therapies, Vaccines & Immunotherapeutics
Administration
Intravenous
01

Overview

IPM001 is a neoantigen/tumor-specific antigen sensitized autoimmune cell therapy with immunostimulating and potential antineoplastic activities. It consists of autoimmune cells that have been sensitized to liver cancer neoantigens and tumor-associated antigens (TAAs). The therapy involves collecting a patient's immune cells, sensitizing them to multiple tumor-associated antigens and neoantigens/tumor-specific antigens from liver cancer cells, and then reinfusing these modified cells back into the patient to enhance the immune system's ability to recognize and attack cancer cells specifically. IPM001 is primarily being investigated for the treatment of hepatocellular carcinoma (HCC), particularly in patients with progressive disease or those at high risk of recurrence after surgical resection.

Other names
liver cancer neoantigens-sensitized autoimmune cells IPM001neoantigen/tumour-specific antigen sensitized autoimmune cell therapymultiple tumor-associated antigen (TAA) and neoantigen/tumor-specific antigen (TSA) sensitized autoimmune cell injectionautoimmune cell therapy sensitized with liver cancer neoantigen
02

Targets

pMHC-II (Peptide-major histocompatibility complex class II complex)

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