Ipomoea aquatica-derived exosome-like nanoparticles

Ipomoea aquatica-derived exosome-like nanoparticles (IA-ELNs) are plant-derived extracellular-like nanoparticles isolated from the leaves of *Ipomoea aquatica* (water spinach). Developed by the Korea Atomic Energy Research Institute, these nanoparticles are being investigated for their potential in cancer immunotherapy. IA-ELNs function by activating dendritic cells (DCs) and promoting Th1-polarized anti-tumor immune responses. Mechanistically, they enhance DC maturation by upregulating surface markers such as CD80, CD86, MHC-I, and MHC-II, and stimulating the secretion of pro-inflammatory cytokines like IL-12p70 and TNF-α. This activation is mediated through the phosphorylation of ERK, JNK, and p38 MAPKs, as well as the activation of the NF-κB signaling pathway, ultimately leading to the proliferation of CD4+ and CD8+ T cells.

Other names

IA-ELNsIpomoea aquatica-derived extracellular-like nanoparticleswater spinach-derived exosome-like nanoparticleswater spinach-derived extracellular-like nanoparticles