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Ipomoea obscura extract is a botanical extract derived from the aerial parts (primarily leaves and stems) of Ipomoea obscura, a perennial climbing herb widely distributed in India and Southeast Asia. Traditionally used in Ayurveda and Siddha medicine, it is recognized for its application in treating conditions such as diarrhoea, ulcers, wounds, inflammatory disorders, and for its analgesic and immunomodulatory effects[4][1][6]. Scientific studies demonstrate a broad range of pharmacological activities including anti-inflammatory, antioxidant, antibacterial, antifungal, anti-angiogenic, anti-tumor, nephroprotective, and immunomodulatory properties[3][4][5]. Mechanistically, its anti-inflammatory and immunomodulatory effects are attributed to the inhibition of key pro-inflammatory cytokines (such as TNF-α, IL-1β, IL-6, GM-CSF), inhibition of inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) modulation[3][4]. The extract also downregulates VEGF and matrix metalloproteinase (MMP) production, leading to anti-angiogenic effects[4]. Its antioxidant effect is linked to an enrichment in phenolic compounds and flavonoids, especially quercetin and kaempferol, with additional presence of lupeol and β-sitosterol[5]. The plant is not a synthetic pharmaceutical product but is commonly curated as a dietary supplement or as part of botanical therapeutics in complementary medicine.
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