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Iprazochrome
- Development stage
- Phase 3
- Lead developer
- Sandoz
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Iprazochrome is a small molecule drug classified as an indole derivative and functions primarily as a serotonin (5-HT2D) receptor antagonist. It is used for the prophylaxis of migraine attacks and for both the treatment and prevention of diabetic retinopathy, particularly in people with type 2 diabetes. Chemically, it is a derivative of adrenochrome, itself an oxidation product of adrenaline. Iprazochrome decreases blood vessel permeability and fragility, thereby reducing migraine frequency and symptoms but not eliminating them entirely. It also neutralizes other vasoactive compounds such as bradykinin and histamine. The drug has been shown to inhibit platelet aggregation in vitro induced by arachidonate and ADP, though its antiserotonergic action is less potent than that of methysergide[1][6][7].
- Brand names
- DivascanNovochrome
- Other names
- 7248-21-7
02
Targets
5-HT (Serotonin receptors)BK (Bradykinin)
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