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iPS-derived corneal cell therapy

Development stage
Unknown
Lead developer
Cellusion
Modality
iPSCs → Pluripotent Stem Cells → Stem Cell Therapies → Cell Therapies
Administration
Intracameral Injection, Surgical Implantation
01

Overview

iPS-derived corneal cell therapy is a regenerative medicine product consisting of a sheet of corneal epithelial cells derived from allogeneic induced pluripotent stem cells (iPSCs). Developed by Osaka University in collaboration with Sumitomo Pharma, the therapy is designed to treat corneal epithelial stem cell deficiency (LSCD), a condition where the loss of limbal stem cells leads to corneal opacity, edema, and vision loss. The treatment involves the surgical transplantation of a lab-grown cell sheet onto the patient's ocular surface to restore a functional corneal epithelium. This approach aims to provide a stable and transparent corneal surface without the need for autologous tissue or long-term immunosuppression typically required for allogeneic tissue transplants.

Other names
iPS-derived corneal epithelial cell sheetallogeneic iPS-derived corneal epithelial cell sheetiPS-derived corneal cell therapy

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