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IQGAP1 siRNA
- Development stage
- Preclinical
- Lead developer
- Santa Cruz Biotechnology
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Parenteral
01
Overview
IQGAP1 siRNA is a small interfering RNA (siRNA) research reagent designed to silence the expression of the IQ Motif Containing GTPase Activating Protein 1 (IQGAP1) gene. IQGAP1 is a scaffold protein involved in regulating cell signaling, cytoskeleton dynamics, and cell-cell adhesion, and its overexpression is associated with tumor progression, metastasis, and poor prognosis in various cancers, including glioblastoma multiforme (GBM). In preclinical studies, IQGAP1 siRNA has been utilized to inhibit cell proliferation, migration, and invasion in glioma cell lines and to study vascular endothelial growth factor (VEGF) signaling. It is primarily used as a laboratory tool for gene knockdown experiments and is not currently an approved therapeutic agent.
- Other names
- IQGAP1 small interfering RNAIQGAP-1 small interfering RNAIQGAP 1 small interfering RNAsiRNA directed at IQGAP1
02
Targets
IQGAP1
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