IR-775

IR-775 is a hydrophobic near-infrared heptamethine cyanine small-molecule dye used primarily as an experimental phototheranostic agent rather than an approved medicine. In the published literature, it functions as a photosensitizer and photothermal transducer for fluorescence imaging, photodynamic therapy, and photothermal therapy, often after encapsulation into liposomes, polymeric nanoparticles, cyclodextrin nanocarriers, or other delivery systems to improve solubility, tumor delivery, and cellular uptake. Upon near-infrared light irradiation, IR-775 generates reactive oxygen species and heat, enabling image-guided tumor ablation in preclinical cancer models; it has also been used as a fluorescent tracer cargo in drug-delivery studies. The available evidence indicates preclinical development only, with no clear evidence from the provided sources of an approved developer-led pharmaceutical product or commercial brand.

Other names

IR-775 chlorideIR775 chlorideIR 775 chlorideIR775 cyanineIR-775 cyanineIR 775 cyanineIR775 dyeIR-775 dyeIR 775 dyeheptamethine cyanine dye IR775near-infrared dye IR-775