irbesartan + hydrochlorothiazide

Irbesartan + hydrochlorothiazide is a fixed-dose combination medication used to treat high blood pressure (hypertension) in adults whose blood pressure is not adequately controlled with either component alone. It combines two antihypertensive agents with complementary mechanisms: - **Irbesartan** is an angiotensin II receptor blocker (ARB), specifically antagonizing the AT1 subtype of the angiotensin II receptor. By blocking this receptor, it prevents vasoconstriction and aldosterone-mediated sodium retention caused by angiotensin II, leading to relaxation of blood vessels and reduced blood pressure. - **Hydrochlorothiazide** is a thiazide diuretic that acts on the distal convoluted tubule in the kidney to inhibit sodium reabsorption. This increases urinary excretion of sodium and water, reducing plasma volume and thereby lowering blood pressure. The combination provides an additive antihypertensive effect greater than either drug alone[1][4][8]. The product is available as oral tablets in various strengths.

Brand names

AvalideIrbesartan Hydrochlorothiazide BMSIrbesartan/Hydrochlorothiazide Teva

Other names

irbesartan and hydrochlorothiazidehydrochlorothiazide and irbesartanHCTZ/irbesartan