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IRF1 siRNA
- Development stage
- Unknown
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intravenous, Subcutaneous, Intratumoral, Intradermal, Intrathecal, Inhalation, Percutaneous, Parenteral
01
Overview
IRF1 siRNA is a small interfering RNA (siRNA) designed to silence the expression of the Interferon Regulatory Factor 1 (IRF1) gene through RNA interference. In preclinical research, particularly in studies involving multiple myeloma, IRF1 siRNA is utilized to investigate the SLC7A11-IRF1-TXN signaling axis. IRF1 acts as a transcriptional repressor of Thioredoxin (TXN); therefore, its knockdown leads to increased TXN expression, which has been shown to protect cancer cells from ferroptosis. This agent is primarily used as a laboratory research tool to understand mechanisms of cell death and potential therapeutic targets in hematological malignancies.
- Other names
- interferon regulatory factor 1 siRNAsiRNA targeting IRF1
02
Targets
IRF1 (Interferon regulatory factor 1)
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