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irinotecan + fluorouracil + leucovorin calcium
- Development stage
- Phase 4
- Lead developer
- Sanofi
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
Irinotecan + fluorouracil + leucovorin calcium, widely known as FOLFIRI, is a combination chemotherapy regimen primarily used in the treatment of metastatic colorectal cancer. Irinotecan is a topoisomerase I inhibitor that induces DNA damage and apoptosis in rapidly dividing cancer cells. Fluorouracil (5-FU) is an antimetabolite that inhibits thymidylate synthase, disrupting DNA synthesis, while leucovorin calcium (folinic acid) is not a chemotherapy agent itself but enhances the binding of 5-FU to thymidylate synthase, thereby increasing its antitumor efficacy. This regimen has been shown to improve progression-free survival and overall response rates compared to standard fluorouracil and leucovorin therapy alone.
- Brand names
- FOLFIRI
- Other names
- irinotecan de Gramontirinotecan modified de Gramont
02
Targets
TS (Thymidylate synthase)TOP1 (DNA Topoisomerase I)
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