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Irinotecan hydrochloride liposome
- Development stage
- Unknown
- Lead developer
- Luye Pharma
- Modality
- Nanoparticles → Drug Delivery Systems, Small Molecules
- Administration
- Intravenous
01
Overview
LOP002 is a liposomal formulation of irinotecan hydrochloride, a semi-synthetic derivative of camptothecin, being developed by Lee's Pharmaceutical. As a topoisomerase I inhibitor, it works by binding to the topoisomerase I-DNA complex, preventing the religation of single-strand breaks and inducing lethal double-strand DNA damage during the S-phase of the cell cycle. The liposomal encapsulation is designed to improve the therapeutic index of irinotecan by prolonging its circulation time and increasing drug accumulation within tumor tissues via the enhanced permeability and retention (EPR) effect, while potentially reducing systemic toxicities. LOP002 is primarily being investigated for the treatment of metastatic pancreatic cancer and is currently in Phase 3 clinical development in China.
- Other names
- Irinotecan hydrochloride liposome injection
02
Targets
TOP1 (DNA Topoisomerase I)
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