Iris nertschinskia ethanol extract

Iris nertschinskia ethanol extract is a botanical extract derived from the ornamental plant *Iris nertschinskia* (also known as *Xiphion orientale*), which has historically been used in traditional East Asian medicine to treat skin diseases and inflammation. Preclinical research has demonstrated that this extract possesses anti-tumor activity, specifically inducing p53-dependent apoptosis in human breast cancer cell lines (such as MCF7) by promoting p53 phosphorylation, inducing Bax protein expression, and triggering caspase-7 cleavage. Additionally, its cytotoxic effects are modulated by AKT signaling, with cell death induction varying based on the levels of phosphorylated AKT1 and AKT2. A South Korean patent (KR101104269B1) covers a pharmaceutical composition of this extract for cancer prevention and treatment, though it remains in the academic and preclinical stages of research with no commercial developers or clinical trials.

Other names

Iris nertschinskia ethanolic extractIris nertschinskia extractXiphion orientale ethanol extractXiphion orientale extract