iron-carbon nanoparticles

Iron-carbon (Fe/C) nanoparticles, also referred to as SPINs in research contexts, are magnetic nanoparticles engineered for magnetic hyperthermia-based cancer therapy. These nanoparticles are synthesized using a co-precipitation method with optimized precursor ratios to achieve a high saturation magnetization (e.g., 148.6 emu/g). The therapeutic mechanism involves the intratumoral administration of the nanoparticles followed by exposure to an alternating magnetic field (AMF). The AMF causes the nanoparticles to generate localized heat, which induces thermal-mediated cell death (hyperthermia) in the tumor tissue. Preclinical studies in breast cancer (MCF-7) and prostate cancer (DU145) xenograft models have demonstrated that these nanoparticles can induce significant tumor reduction and near-complete regression, depending on the dosage and field exposure.

Other names

Fe/C nanoparticlesiron-carbon SPINsoptimized iron-carbon nanoparticles