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irradiated MMC10-BCSC whole tumor cell vaccine
- Development stage
- Preclinical
- Lead developer
- Cleveland Clinic
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Subcutaneous, Intraperitoneal, Intratumoral
01
Overview
Irradiated MMC10-BCSC whole tumor cell vaccine is an experimental preclinical cancer vaccine derived from breast cancer stem-like cells (BCSC) of the mouse mammary carcinoma (MMC) sub-line MMC10. Developed by researchers at The Cleveland Clinic, the vaccine is designed to stimulate an immune response against HER2/neu-positive breast cancer. In preclinical models, vaccination with irradiated MMC10-BCSCs primes CD4+ and CD8+ T cells, which can be harvested and expanded in vitro to mediate the regression of established pulmonary metastases upon adoptive transfer.
- Other names
- MMC10-BCSC vaccineMMC-10-BCSC vaccineMMC 10-BCSC vaccineirradiated MMC10-BCSC vaccine
02
Targets
CSF2R (Granulocyte-macrophage colony-stimulating factor receptor)
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